Top 3 Prescription Cold Sore Medicines

October 11, 2009

While there is ample information floating around the internet about new cold sore medicines, it is vital to understand the top and the most effective FDA approved prescription cold sore medicines for that would prove to be safe and secure whenever used rather than opting for any other treatment for curing cold sores.

This article lists out the top 2 powerful cold sore medicines based on personal experiences. The latest FDA approved Lipsovir is discussed here in detail as the third prescription cold sore medicine option.

Denavir Cream 1%

Generically available in the form of penciclovir topical, Denavir is an antiviral prescription cold sore medication initially approved by FDA in the year 1996. This medication is intended to be used externally and if used near the eyes or inside the nose is likely to cause irritation.

The recommended dosage entails the application of this cream once in every 2 hours during the day. Approximately, it can be used 9 times a day. However, excessive usage of this cream is strictly prohibited and it has to be used during the tingle stage where the individual starts feeling soreness around the areas of prospective infection. Redness or inflammation in the areas of the lips and mouth insinuates the onset of cold sores. It is vital that you start applying this medication at this stage of the inset of the infection for it to be effective.

Zovirax Cream 5%

Commonly referred to as the acyclovir, it works similar to that of Denavir cream. This prescription cold sore medicine is also applied externally. The recommended dosage entails the external application for 4 times a day. It is quite expensive and is recommended that you apply this cream at the onset of the tingling stage of sold sores. However, this cream has proven to be effective in controlling and healing the blisters after they appear.

Working Principle of Denavir and Zovirax

Both these prescription cold sore medications work by managing and limiting the extent of damage caused by cold sores. However, they are neither intended to be perfect cure for cold sores nor are prescribed as the preventive medications for the contraction of cold sores. As such, even after the application of these creams, it is likely that the herpes virus type 1 lingers in the infected patients’ body and remains passive till another infection or outbreak sets in.


This is the recently FDA approved prescription medicine for cold sores. Being a combination of Acyclovir and hydrocortisone, it helps in preventing ulcerative fever blisters and shortens the healing time of the blisters.

Famvir and valtrex are the other prescription cold sore medicines that are in vogue today. Before resorting to any of these, please make it a point to get your physician’s advice for that would render safe and secure usage of these medicines in the long run.